A well rounded performer who has used his life experience to make a name for himself, is well versed in many aspects of the performing arts, including roles as a chorus singer/soloist, composer, percussionist, songwriter, and actor. With a strong history of singing traditional salsa and Cuban charangas, Domingo also became accomplished in rumba and bachata. His career began in 1983 with New York's El Conjunto Nativo and flourished as he worked with various orchestras including Johnny Rodriguez and Conjunto Classico, Jose Alberto "El Canario," and Luis "Perico" Ortiz, as lead vocalist.

A contract from RMM Records in 1987 opened the door for Qui-ones to release many hits and work on duets with artists such as Tito Puente, Van Lester, and Tony Vega. He released numerous recordings between 1987 and 1998 and made his theatrical debut in The Vietnam War Story, (Heroes De La Patria). He also played Ponctius Pilate at Puerto Rico's Centro de Bella Artes in the musical Jesucristo Superstrella (Jesus Christ, Superstar). However, Dominigo Quinones has been most acclaimed for his role as the famous Salsa Singer, Hector LaVoe, in the off Broadway play, "їQuien Matу a Hector LaVoe?" His ability to evoke the essence of this controversial and complicated artist is heightened through Qui-ones own battle with demons. A life-changing religious awakening helped him to overthrow a drug dependency that would surely have obstructed his ability to become one of Puerto Rico's most popular performers.